Preparation of coated granular ibuprofen microsphere

Details Preparation of coated granular ibuprofen microsphere Preparation of coated granular ibuprofen microsphere

1986-11-25

1988-02-23

Lovering, Richard D.

Coating processes

Particles, flakes, or granules coated or encapsulated

Solid encapsulation process utilizing an emulsion or...

424462, 424497, 514570, 514963, 514974, B01J 1302

Patent

active

047269669

ABSTRACT:
This invention provides a simple method for preparing granular ibuprofen microsphere whose surface is coated with acrylic acid resin. By this method granulation of ibuprofen and coating of its surface can be simultaneously accomplished. Namely, the method of preparation includes the steps of: (a) dissolving ibuprofen with acrylic acid resin into lower aliphatic alcohol, acetone, methylene chloride or N,N-dimethylformamide; and (b) depositing coated granular ibuprofen microsphere by mixing the solution of step (a) with water and by stirring the mixed solution.

REFERENCES:
patent: 3737337 (1973-06-01), Schnoring et al.
patent: 3859228 (1975-01-01), Morishita et al.
patent: 4457907 (1984-07-01), Porter

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