Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-04-17
2007-04-17
Dentz, Bernard (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C549S457000
Reexamination Certificate
active
10496277
ABSTRACT:
The present invention concerns a process for preparing each of the 4 individual diastereomers of formula (I) in stereochemically pure form from a single enantiomerically pure precursor. The tetracyclic ringsystem having cis-fused five and seven membered rings is formed in a base-catalysed cyclization reaction. The invention further relates to the thus obtained cis-fused tetracyclic alcohol intermediates and methanamine end-products, and the methanamine end-products for use as a medicine, in particular as CNS active medicines
REFERENCES:
patent: WO 97/38991 (1997-10-01), None
patent: WO 99/19317 (1999-04-01), None
Monkovic, I., et al., “Substituted Tetrahydrofurfurylamines as Potential Antidepressants” Journal of Medicinal Chemistry, 1973, vol. 16, No. 4, pp. 403-407.
Compernolle, et al., Tetrahedron Letters, “Stereoselective synthesis of transfused tetrahydrofuran derivatives of 5H-dibenzo[a,d]cycloheptene”, vol. 43, pp. 3011-3015, 2002, XP002237856.
Compernolle Frans Josef Cornelius
Hoornaert Georges Joseph Cornelius
Hua Mao
Kozlecki Tomasz
Dentz Bernard
Woodcock & Washburn LLP
LandOfFree
Preparation of cis-fused... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Preparation of cis-fused..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of cis-fused... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3757915