Preparation of cis-4-O-protected-2-cyclopentenol derivatives

Details Preparation of cis-4-O-protected-2-cyclopentenol derivatives Preparation of cis-4-O-protected-2-cyclopentenol derivatives

1997-06-17

1998-09-15

Owens, Amelia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 13, 549 28, 549 62, 549 78, 549 80, 556470, 568379, 568667, 568731, 568838, C07D31500

Patent

active

058081127

ABSTRACT:
The present invention relates to a novel process for preparing cis-4-O-protected-substituted-2-cyclopentenol derivatives comprising, a) dissolving a 4-O-protected-2-cyclopentenone in a suitable organic solvent; and b) treating the solution with a suitable Lewis acid and a suitable reducing agent at a temperature of from about -100.degree. C. to about 20.degree. C. The cis-4-O-protected-substituted-2-cyclopentenol derivatives are useful intermediates in the preparation of various cyclopentanyl and cyclopentenyl purine analogs which are useful as immunosuppressants and in the preparation of various prostaglandins.

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