Preparation of chiral resolution

Details Preparation of chiral resolution Preparation of chiral resolution

1995-04-11

1997-11-11

Datlow, Philip I.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 72, C07D47108

Patent

active

056866143

ABSTRACT:
Disclosed are processes for resolving a racemic mixture of enantiomers comprising recrystallizaton of diasteriomeric tartrate salts.

REFERENCES:
patent: 4399141 (1983-08-01), Anderson et al.
patent: 4477668 (1984-10-01), Bender et al.
patent: 5196415 (1993-03-01), Monn et al.
Rogawski, et al., (1991), "Anticonvulsant Activity of Low-Affinity Uncompetitive N-Methyl-D-aspartate Antagonist (.+-.)-5-Aminocarbonyl-10, the Structural Analogs Dizocilpine (MK-801) and Carbamazepine," J. Pharmacology and Experimental Therapeutics, vol. 259, No. 1, pp. 30-37.
Grant, et al., (1991), J. Pharmacology and Experimental Therapeutics, vol. 260, No. 3, pp. 1017-1022.

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