Preparation of chiral 1,4-benzodiazepin-2-one-derivatives by rea

Details Preparation of chiral 1,4-benzodiazepin-2-one-derivatives by rea Preparation of chiral 1,4-benzodiazepin-2-one-derivatives by rea

1974-07-29

1977-03-01

Jiles, Henry R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260562N, 424244, C07D24348

Patent

active

040101533

ABSTRACT:
A process is disclosed for preparing optically active 1,4-diazepine-2-ones by reacting an acid chloride-hydrochloride of an optically active .alpha.-amino acid with a substituted o-amino benzophenone, to form an intermediate product and subsequently cyclizing the intermediate product to form the desired 1,4-diazepine-2-one. The process is carried out in inert organic or aqueous-organic solvents. The process eliminates the need for using .alpha.-amino acids having bound to the amino group a protective group which must be removed before cyclization.

REFERENCES:
patent: 3371085 (1968-02-01), Reeder et al.
Bell et al., "J. Org. Chem.," vol. 27, pp. 560-566 (1962).
Chemical Abstracts, vol. 80, (1974), p. 345, Item 70786m, Abstracting Sunjic et al., in "Acta Pharm. Jugoslav," (1973), vol. 23, No. 4, pp. 213-217.
Sunjic et al., in "Acta Pharm. Jugoslav.," (1973), vol. 23, No. 4, pp. 213-217.
Sunjic et al., in "J. Het. Chem.," (1973), vol. 10, pp. 591-599.

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