Preparation of cephalosporin intermediate compounds

Details Preparation of cephalosporin intermediate compounds Preparation of cephalosporin intermediate compounds

1983-05-26

1985-12-10

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 16, 544 26, 2602452R, 260239A, 2602391, C07D50124, A61K 31545

Patent

active

045581240

ABSTRACT:
There is described a process for preparing a sulphoxide of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4, taken individually, are alkyl, alkoxy or aryl groups, X is an alkylene group, R.sup.5 is a carboxylic acid protecting group and Y is a linking group through one or two carbon atoms forming a penam or cephem nucleus, which comprises reacting a compound of formula ##STR2## with an oxidizing agent. .alpha.-Sulphoxide compounds of formula (I) are also provided as novel intermediates.

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W. Durckheimer et al., HR 109, A Highly Active Cephalosporin etc., Recent Advances in the Chemistry of .beta.-Lactam Antibiotics, G. I. Gregory, Ed., Royal Society of Chemistry, London, 1981, pp. 48-49.
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