Preparation of candesartan cilexetil

Details Preparation of candesartan cilexetil Preparation of candesartan cilexetil

2006-08-29

2006-08-29

Solola, Taofiq (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S252000

Reexamination Certificate

active

07098342

ABSTRACT:
The invention encompasses processes for the synthesis of cilexetil trityl candesartan from the reaction of trityl candesartan with cilexetil halide in the presence of a base and a low boiling organic solvent. Optionally, the reaction may be conducted in the presence of a phase transfer catalyst.

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Matsunaga, et al.: “Solid-State Characterization of Candesartan Colexetil (TCV-116): Crystal Structure and Molecular Mobiluty”, Chem. Pharm. Bull. 47 (2), pp. 182-186 (1999).

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