Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1976-03-11
1977-10-04
Thomas, Jr., James O.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260534C, C07C 9904, C07C 9910
Patent
active
040524515
ABSTRACT:
Beta-amino propionitrile is hydrolyzed with potassium hydroxide to produce potassium beta alanate, which, upon acidification produces free beta alanine with some potassium sulfate precipitate. The beta alanine solution with residual potassium sulfate is concentrated under vacuum to a thick syrup, shocked with an excess of a selected alcohol to produce a solid mass of beta alanine with the remaining theoretical potassium sulfate. The solid product is converted to calcium beta alanate under anhydrous conditions for reaction with racemic pantoyl lactone to form pure calcium pantothenate and allowing the entrained potassium sulfate to settle out. Contrary to expectations, under these conditions there was no double displacement and the presence of potassium sulfate did not interfere with the reaction.
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Morrison et al., Organic Chem., 3d ed. Allyn & Bacon, Inc., Boston, 588-589 (1974).
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Breitenstein G.T.
Brown Paul L.
Thomas Bruce K.
Thomas, Jr. James O.
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