Preparation of brominated paclitaxel analogues and their use as

Details Preparation of brominated paclitaxel analogues and their use as Preparation of brominated paclitaxel analogues and their use as

1996-05-29

1998-09-15

Trinh, Ba K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549510, 549511, A61K 31335, C07D30514

Patent

active

058078886

ABSTRACT:
Provided are novel paclitaxel analogues, namely selectively brominated stereospecific derivatives of cephalomannine and 7-epi-cephalomannine having in vivo and in vitro paclitaxel-like antitumor efficacy, methods of preparation therefor and methods for treating tumors with these compounds.

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