Preparation of bis(salicyl) diesters

Details Preparation of bis(salicyl) diesters Preparation of bis(salicyl) diesters

1989-12-05

1991-08-20

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

546342, C07C 6714, C07D21355

Patent

active

050416154

ABSTRACT:
Bis(salicyl) diesters useful as cross-linking agents for hemoglobin are prepared in high yield and purity by reacting salicylic acid or a derivative thereof with a lower aliphatic dicarboxylic acid halide in a lower aliphatic ketone or nitrile solvent in the presence of a pyridine derivative. The desired diester is recovered from the resulting insoluble pyridine derivative salt.

REFERENCES:
patent: 874929 (1907-12-01), Berendes et al.
Zaugg et al., J. Biol. Chem., 225:2816, (1980).
Walder et al., Biochem., 18:4265, (1979).

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