Preparation of biologically active compounds from substantially

Details Preparation of biologically active compounds from substantially Preparation of biologically active compounds from substantially

1995-06-05

1997-11-18

Naff, David M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435121, 435128, 435136, 435147, 435227, 435280, 544265, 548543, C07H 100, C07D43700, C12P 1710

Patent

active

056889330

ABSTRACT:
Lactams of 1-amino-3-carboxylic acid cyclic compounds are provided in enantiomeric form, together with an enantiomer of the corresponding ring-opened amino-acid or ester, by reaction of the racemic lactam with a novel lactamase. The products are useful in the synthesis of chiral carbocyclic nucleotides. The enantiomer is preferably

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Evans et al., J. Chem. Soc. Perkin Trans., vol. 1:656-657, (1991).
Caamano et al., "An Approach To The Enantioselective Synthesis of 2839-2841, (1988).
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Chemical Abstracts, vol. 107, No. 5, Aug. 3, 1987, p. 648, Abstract No. 39244k, Columbus, OH; R.D. Allan et al., "Gamma-Aminobutyric Acid Synthesis Of Analogs of GABA. XV.", and Chemical Abstract, vol. 107, Chemicals Substances Index, Part 2, 1987, p. 2891CS, & Australian Journal of Chemistry, 1986, 39(6), 855-864.
Chemical Abstracts, vol. 91, No. 25, Dec. 17, 1979, p. 25, Abstract No. 204205j, Columbus, OH; G.A.R. Johnston et al., "Stereospecific Actions of GABA Analogs", and ADV Pharmacol Ther., Pro. Int. Congr. Phamacol, 7th 1978 (Pub. 1979) 2, 11-18.
Journal of Organic Chemistry, vol. 43, No. 12, Jun. 9, 1978, pp. 2311-2320, American Chemical Society, Washington, D. C., S. Daluge et al., "Synthesis of Carbocyclic Aminucleosides".

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