Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Treating polymer containing material or treating a solid...
Reexamination Certificate
2009-04-09
2011-12-13
Boykin, Terressa (Department: 1765)
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Treating polymer containing material or treating a solid...
C514S007600, C514S009100, C514S259410, C528S271000, C528S272000
Reexamination Certificate
active
08076448
ABSTRACT:
The invention provides methods of extracting a biodegradable polyester with a supercritical fluid effective to obtain a purified biodegradable polyester, such as a purified biodegradable poly(lactide-glycolide) (PLG). The supercritical fluid can be carbon dioxide at an elevated pressure, or can be carbon dioxide with one or more cosolvents. Methods for carrying out stepwise purification of the biodegradable polyester at multiple pressures or multiple temperatures, or both, are also provided. When the polyester is PLG, a purified PLG copolymer is obtained having a narrowed molecular weight distribution with respect to the unpurified polyester. The purified PLG copolymer can have a polydispersity index of less than about 1.7, less than about 2% monomers, and less than about 10% oligomers. The purified PLG copolymer can exhibit a reduced initial burst effect when incorporated into a controlled release formulation such as a flowable implant adapted to be injected into body tissues.
REFERENCES:
patent: 4728721 (1988-03-01), Yamamoto et al.
patent: 4810775 (1989-03-01), Bendix et al.
patent: 4938763 (1990-07-01), Dunn et al.
patent: 5324519 (1994-06-01), Dunn et al.
patent: 5478921 (1995-12-01), Roby et al.
patent: 5585460 (1996-12-01), Yamada et al.
patent: 5702716 (1997-12-01), Dunn et al.
patent: 5744153 (1998-04-01), Yewey et al.
patent: 5981694 (1999-11-01), Gruber et al.
patent: 5990194 (1999-11-01), Dunn et al.
patent: 6143314 (2000-11-01), Chandrashekar et al.
patent: 6261583 (2001-07-01), Dunn et al.
patent: 6395293 (2002-05-01), Polson et al.
patent: 6461631 (2002-10-01), Dunn et al.
patent: RE37950 (2002-12-01), Dunn et al.
patent: 6528080 (2003-03-01), Dunn et al.
patent: 6565874 (2003-05-01), Dunn et al.
patent: 6630155 (2003-10-01), Chandrashekar et al.
patent: 6773714 (2004-08-01), Dunn et al.
patent: 6966990 (2005-11-01), Chattopadhyay et al.
patent: 7019106 (2006-03-01), Yamamoto et al.
patent: 2006/0074010 (2006-04-01), Chattopadhyay et al.
patent: WO-2008045516 (2008-04-01), None
Formation of polymer particles with supercritical fluids: A review The Journal of Supercritical Fluids, vol. 34, Issue 3, Jul. 2005, pp. 287-308 Sang-Do Yeo, Erdogan Kiran.
“European Application Serial No. 07839468.1, Communication mailed May 19, 2009”, 2 pgs.
“European Application Serial No. 07839468.1, Response filed Jun. 19, 2009 to Communication mailed May 19, 2009”, 4 pgs.
“European Application Serial No. 07839468.1, Supplementary European Search Report mailed Dec. 29, 2009”, 5 pgs.
“International Application Serial No. PCT/US07/21749, International Search Report mailed Jan. 30, 2008”, 3 pgs.
“International Application Serial No. PCT/US07/21749, Written Opinion mailed Jan. 30, 2008”, 6 pgs.
Taylor, L. T., “Chapter 2—Properties of Supercritical Fluids”,Supercritical Fluid Extraction, John Wiley & Sons, Inc., New Nork, NY, (1996), 7-27.
Vilegas, J. H. Y., et al., “Extraction of Low-Polarity Compounds (with Emphasis on Coumarin and Kaurenoic Acid) from Mikania glomerata (‘Guaco’) Leaves”,Phytochemical Analysis, 8(5), (1997), 266-270.
“Canadian Application Serial No. 2,666,341, Voluntary Amendment filed Mar. 16, 2010”, 5 pgs.
“Canadian Application Serial No. 2666341, Office Action mailed Sep. 7, 2010”, 2 pgs.
“European Application Serial No. 07839468.1, Office Action mailed Jul. 28, 2010”, 4 pgs.
“European Application Serial No. 07839468.1, Office Action Response Filed Dec. 7, 2010”, 6 pgs.
“U.S. Appl. No. 12/421,535, filed Mar. 1, 2011 to Office Action mailed Sep. 7, 2010”, 18 pgs.
Yeo, et al., “Formation of polymer particles with supercritical fluids”,A review. Journal of Supercritical Fluids, vol. 34(3), (2005), 287-308.
Moore Lester
Norton Richard L.
Boykin Terressa
Schwegman Lundberg & Woessner, P.A.
Tolmar Therapeutics, Inc.
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