Preparation of biodegradable microspheres useful as carriers for

Details Preparation of biodegradable microspheres useful as carriers for Preparation of biodegradable microspheres useful as carriers for

1986-05-16

1988-05-03

Lovering, Richard D.

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

264 43, 424 79, 424 85, 424 88, 424 943, 424 9464, 424486, 424487, 424501, 42840222, 514963, A61K 926, A61K 952, A61K 958, B01J 1302

Patent

active

047418729

ABSTRACT:
A method for preparing biodegradable microspheres having a three-dimensional network in which biologically active macromolecular agents are physically entrapped therein. The microsphere is able to degrade and release the macromolecular agent at a controlled rate. The method involves emulsifying a vinyl derivative of a biodegradable hydrophilic polymer, a water-soluble monovinyl monomer and a biologically active macromolecule in water, and copolymerizing the biodegradable hydrophilic polymer and the water-soluble monovinyl monomer such that the biologically active macromolecule is entrapped therein.

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patent: 3786123 (1974-01-01), Katzen
patent: 4049604 (1977-09-01), Morehouse, Jr. et al.
patent: 4094833 (1978-06-01), Johansson et al.
patent: 4178361 (1979-12-01), Cohen et al.
patent: 4247406 (1981-01-01), Widder et al.
patent: 4356166 (1982-10-01), Peterson et al.

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