Preparation of biodegradable microparticles containing a biologi

Details Preparation of biodegradable microparticles containing a biologi Preparation of biodegradable microparticles containing a biologi

1996-10-03

1997-07-22

Hulina, Amy

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424497, 264 41, 264 46, 4272133, 42721336, A61K 950, B01J 1302

Patent

active

056501730

ABSTRACT:
Disclosed herein is a process for preparing biodegradable microparticles comprising a biodegradable polymeric binder and a biologically active agent, wherein a blend of at least two substantially non-toxic solvents, free of halogenated hydrocarbons, is used to dissolve or disperse the agent and dissolve the polymer. The solvent blend containing the agent and polymer is dispersed in an aqueous solution to form microdroplets. The resulting emulsion is then added to an extraction medium preferably containing at least one of the solvents of the blend, whereby the rate of extraction of each solvent is controlled, whereupon the biodegradable microparticles containing the biologically active agent are formed.

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