Preparation of biodegradable microparticles containing a biologi

Details Preparation of biodegradable microparticles containing a biologi Preparation of biodegradable microparticles containing a biologi

1996-10-10

1997-08-05

Hulina, Amy

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424497, 264 41, 264 46, 4272133, 42721336, A61K 950, B01J 1302

Patent

active

056540086

ABSTRACT:
A process for preparing biodegradable microparticles comprising a biodegradable polymeric binder and a biologically active agent. A first phase, comprising the active agent and the polymer, and a second phase are pumped through a static mixer into a quench liquid to form microparticles containing the active agent. Preferably, a blend of at least two substantially non-toxic solvents, free of halogenated hydrocarbons, is used to dissolve or disperse the agent and dissolve the polymer.

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