Preparation of biodegradable microcapsules based on serum albumi

Details Preparation of biodegradable microcapsules based on serum albumi Preparation of biodegradable microcapsules based on serum albumi

1985-06-04

1987-05-19

Lovering, Richard D.

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

264 47, 424491, 424 19, 424 36, 4284022, 514963, A61K 952, A61K 964, B01J 1302

Patent

active

046666419

ABSTRACT:
The present invention relates to biodegradable microcapsules based on serum albumin, the preparation thereof and the application thereof to the release of drugs in situ.
A feature of the microcapsules according to the present invention is that their wall consists of serum albumin, a portion of which is crosslinked by interfacial polymerization with the aid of an acylating bifunctional reagent, and the other, non-crosslinked portion of which is denatured by means of an alcohol.

REFERENCES:
patent: 3137631 (1964-06-01), Soloway
patent: 4107288 (1978-08-01), Oppenheim et al.
patent: 4115534 (1978-09-01), Ithakissios
patent: 4147767 (1979-03-01), Yapel, Jr.
patent: 4251387 (1981-02-01), Lim et al.
patent: 4331654 (1982-05-01), Morris
patent: 4419340 (1983-12-01), Yolles

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