Preparation of biodegradable, biocompatible microparticles conta

Details Preparation of biodegradable, biocompatible microparticles conta Preparation of biodegradable, biocompatible microparticles conta

1999-03-05

2000-08-29

Azpuru, Carlos A.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424502, 264 433, 264 46, 42840221, A61K 950, B01J 1302, B32B 516, B32B 1502

Patent

active

061105031

ABSTRACT:
A method for preparing biodegradable, biocompatible microparticles. A first phase is prepared that includes a biodegradable, biocompatible polymer, an active agent, and a solvent. An immiscible second phase is prepared. The first and second phases are combined to form an emulsion in which the first phase is discontinuous and the second phase is continuous. The two phases are immersed in a quench liquid that includes a quench medium and a quantity of the solvent. The quantity of the solvent is selected to control a rate of extraction of the solvent from the first phase. The first phase is isolated in the form of microparticles. Also disclosed is a microencapsulated active agent prepared by the method for preparing biodegradable, biocompatible microparticles.

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