Preparation of biocompatible materials by immobilization of apyr

Details Preparation of biocompatible materials by immobilization of apyr Preparation of biocompatible materials by immobilization of apyr

1981-12-28

1983-08-02

Naff, David M.

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

Enzyme or microbial cell is immobilized on or in an organic...

3 1, 435180, C12N 1106, C12N 1108, A61F 100

Patent

active

043967167

ABSTRACT:
A prosthetic polymer material is made non-thrombogenic by immobilizing apyrase on its surface. Immobilization is preferably carried out by hydrolytically activating the surface of a polyamide polymer or a polyethylene terphthalate polymer, and treating the hydrolyzed polymer with a solution of cross-linking agent and a solution of apyrase. The apyrase converts adenosine diphosphate to adenosine monophosphate and adenosine whereby the formation of thrombi is inhibited.

REFERENCES:
patent: 3705084 (1972-12-01), Reynolds
patent: 3865915 (1975-02-01), Manly
patent: 4273873 (1981-06-01), Sugitachi et al.
Patel et al., In Soluble Matrix-Supported Apyrase, Deoxyribonuclease and Cholinesterase Biochim. Biophys. Acta, vol. 178, 1969, (pp. 626-629).
Gaarder et al., Adenosine Diphosphate in Red Cells as a Factor in the Adhesiveness of Human Blood Platelets, Nature, vol. 192, 1961, (pp. 531-532).

Affiliated with

Also associated with

Rating

Preparation of biocompatible materials by immobilization of apyr does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of biocompatible materials by immobilization of apyr, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of biocompatible materials by immobilization of apyr will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-484466