Preparation of bicyclohexane derivative

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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562 5, 562500, 562501, 562509, 514393, C07D23502, C07D48720, C07C 6112, C07C 6128, A61K 31415

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active

057263205

ABSTRACT:
A process for the preparation of pharmaceutically acceptable salt thereof, which comprises hydrolysing thereof, and optionally forming a pharmaceutically acceptable salt. Also disclosed are intermediates useful in the process.

REFERENCES:
patent: 2560584 (1951-07-01), McDonald
patent: 2629660 (1953-02-01), Harsh
patent: 2732380 (1956-01-01), Reppe et al.
patent: 2762708 (1956-09-01), Maekey
patent: 3271245 (1966-09-01), Cremlyn et al.
patent: 3532744 (1970-10-01), Fletcher et al.
patent: 3594413 (1971-07-01), Alburn et al.
patent: 3704312 (1972-11-01), Russel et al.
patent: 3716553 (1973-02-01), Alburn et al.
patent: 3725423 (1973-04-01), Rynbrandt
patent: 3746495 (1973-07-01), Malis et al.
patent: 3823177 (1974-07-01), Fanta et al.
patent: 4315031 (1982-02-01), Vincent et al.
patent: 4320135 (1982-03-01), Kathawala
patent: 4861913 (1989-08-01), Narisada et al.
patent: 5228898 (1993-07-01), Ueda et al.
Y. Nakagawa et al., "(2S,3S,4S).alpha.-(Carboxycyclopropyl)-glycine is a novel agonist of metabotropic glutamate receptors," European J. Pharmacology, 184, 205-206 (1990).
Y. Hayashi et al., "Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells," Br. J. Pharmacol., 107, 539-543 (1992).
H. Shinozaki and M. Ishida, "Recent Advances in the Study of Glutamate Receptor Agonists," Asia Pacific J. of Pharmacol., 6, 293-316 (1991).
F. Nicoletti et al., "(2s, 1'.sub.R, 2'.sub.R, 3'.sub.R)-2-(2,3-Dicarboxycyclopropyl)glycine enhances quisqualate-stimulated inositol phospholipid hydrolysis in hippocampal slices," Eur. J. Pharmacol.-Molecular Pharmacol. Section, 245, 297-298 (1993).
M. Ishida et al., "A potent metabotropic glutamate receptor agonist: electrophysiological actions of a conformationally restricted glutamate analogue in the rat spinal cord and Xenopus oocytes," Brain Res., 537, 311-314 (1990).
M. Ishida et al., "A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the newborn rat isolated spinal cord," Br. J. Pharmacol., 109, 1169-1177 (1993).
V. Bruno et al., "Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death," Eur. J. Pharmacol., 256, 109-112 (1994).
H. Kaba et al., "Induction of an Olfactory Memory by the Activation of a Metabotropic Glutamate Receptor," Science, 265, 262-264 (Jul. 8, 1994).
D.E. Jane et al., "Actions of two new antagonists showing selectively for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord," Br. J. Pharmacol., 112, 809-816 (1994).
F. Nicoletti et al., "Effect of Metabotropic Glutamate Receptor Agonists on Excitotoxic or Apoptotic Neuronal Degeneration," Neuropschychopharmacology, 10 (3S), 623S (1994).
J. Greenstein et al, "Chemistry of the Amino Acids", John Wiley & Sons, Inc (New York), 6, 2559-2567 (1961).
D.D. Schoepp, et al., European Journal of Pharmacology, vol. 207, 1991, pp. 351-353.
G. Costantino, et al., "Definition of a Pharmacophore for the Metabotropic Glutamate Receptors Negatively Linked to Adenylyl Cyclase", Bioorganic & Medicinal Chemistry, 1, 259-265 (1993).

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