Preparation of biaryl compounds

Details Preparation of biaryl compounds Preparation of biaryl compounds

1989-08-03

1990-04-10

Sneed, H. M. S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

585469, 564155, 568642, 568643, 570129, 562405, C07D21326, C07C10320, C07C 4302, C07C 120

Patent

active

049162276

ABSTRACT:
A method for the preparation of biaryl compounds is disclosed which comprises contacting an aromatic halide in the presence of a catalyst comprising zerovalent nickel, a bidentate phosphorus-containing coordinating ligand and a reducing metal in a polar, aprotic solvent system for a time and under conditions suitable for the formation of biaryl compound.

REFERENCES:
patent: 4263466 (1981-04-01), Colon et al.
"Nickel-Phosphine Complex Catalyzed Homocoupling of Aryl Halides in the Presence of Zinc Copper", Zembayashi et al., Tet. Lett. 47: 4089-4092 (1977).
"Coupling of Aryl Chlorides by Nickel and Reducing Metals", Colon et al., J. Org. Chem. 51: 2627-2637 (1986).

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