Preparation of .beta.lactam compounds

Details Preparation of .beta.lactam compounds Preparation of .beta.lactam compounds

1995-04-18

1996-10-08

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540200, 540214, 540215, 540300, 540301, 540302, 540357, 540364, C07D46300, C07D47700, C07D50108, C07D49906

Patent

active

055632645

ABSTRACT:
A process for preparing a .beta.-lactam compound of the formula (I): ##STR1## which comprises cyclization, in the presence of a catalyst, of an azetidinone derivative of the formula: ##STR2## is provided in which R.sup.1 is hydrogen, alkyl which is optionally substituted, or amino which is optionally substituted; R.sup.2 is a carboxy-protecting group; and X is alkylene which is optionally intervened by --O-- or --S--, and/or which is optionally substituted; and R.sup.3 is aryl which is optionally substituted. The catalyst is preferably a transition metal salt (especially rhodium) or is an acid.

REFERENCES:
patent: 4122086 (1978-10-01), Hall
Moriarty, Zet. Letters 34, 4129 (1993).
Kalogiannis et al., The Journal of Organic Chemistry, vol. 55, No. 17 (1990) pp. 5041-5044.
Fairfax et al., Journal of The Chemical Society, Perkin Transactions 1, No. 21 (1992) pp. 2837-2844.

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