Preparation of bacterium pili subunits and vaccines containing p

Details Preparation of bacterium pili subunits and vaccines containing p Preparation of bacterium pili subunits and vaccines containing p

1986-08-14

1987-10-27

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

530418, 530420, 530825, A61K 39108, A61K 3902, A61K 39116, C07K 328

Patent

active

047029110

ABSTRACT:
A method for obtaining bacterium pili subunits directly from specified bacteria is disclosed and claimed. Dependent upon the bacterium from which the pili subunits are to be obtained, the pH of extraction solutions will be adjusted accordingly. Pili subunits obtained in accord with the method of this invention are useful for preparing vaccines which exhibit good protection against heterologous strain infections.

REFERENCES:
patent: 4237115 (1980-12-01), Brinton, Jr.
patent: 4298597 (1981-11-01), Acres et al.
patent: 4454116 (1984-06-01), Brinton, Jr.
patent: 4472302 (1984-09-01), Karkhanis
J. of Bacteriology, 138, No. 3 (1979), 969-975, McMichael et al.
FEMS Microbiology Letters, 12 (1981), 229-232, Isaacson et al.
Annals of Clinical Research, 14 (1982), 272-277, Korhonen et al.

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