Preparation of asymmetric iminodibenzyl compounds

Details Preparation of asymmetric iminodibenzyl compounds Preparation of asymmetric iminodibenzyl compounds

1973-07-24

1977-03-22

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260571, 260578, 260580, 260612R, 260645, 260646, 260954, C07D22328

Patent

active

040136396

ABSTRACT:
Iminodibenzyl derivatives of the formula: ##SPC1##
Wherein R and R.sup.1 each represent hydrogen, halogen, amino, sulfamoyl, lower alkyl, lower alkoxy or lower alkanoyl, provided that R and R.sup.1 can not both be hydrogen and when R and R.sup.1 are the same, they are located at positions asymmetric to each other, are produced in high purity and yield by a series of reactions which proceed through novel 2,2'-dinitrostilbene or 2,2'-diaminostilbene and 2,2'-diaminodibenzyl derivatives. The reaction sequence involves condensation, reduction and ring-closure reactions to give asymmetric as well as symmetric iminodibenzyl derivatives. The resulting iminodibenzyl derivatives may be converted to useful pharmaceutical compounds having anti-depressant, analgesic or anti-allergic properties.

REFERENCES:
patent: 2764580 (1956-09-01), Schindler et al.
patent: 3068222 (1962-12-01), Craig
Horner et al., Ber. Deut. Chem., vol. 91, pp. 61-63, (1958).
Seus et al., J. Org. Chem., vol. 26, p. 5243 (1961).

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