Preparation of ascorbic acid granules

Details Preparation of ascorbic acid granules Preparation of ascorbic acid granules

1985-12-18

1989-01-24

Lusignan, Michael

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424 80, A61K 916

Patent

active

048000868

ABSTRACT:
Ascorbic acid granules for direct tableting are prepared by the compacting method, wherein the ascorbic acid in the form of crystals or crystal fragments, of which not more than 40% by weight have a longest particle diameter of less than 50 .mu.m and not more than 15% by weight have a longest particle diameter greater than 500 .mu.m, and as a mixture with from 0.8 to 8% by weight of soluble polyvinylpyrrolidone having a water content of from 0.3 to 5% is compacted in a conventional manner, and the product is comminuted.

REFERENCES:
patent: 2820741 (1958-01-01), Endicott et al.
patent: 4036948 (1977-07-01), Kitamori et al.
patent: 4203997 (1985-05-01), Kuppers et al.
Peter C. Schmidt, Deutsche Apotheker Zeitung, 122 Jahrg. Nr. 3, (1982), p. 111, FIG. 12, and p. 110, Top of Right Column.
S. P. Gladkikh, Khimiko-Farmatsevticheskii Zhurnal, vol. 4, No. 12, pp. 37-42, Dec. 1970.
S. Lee et al., J. Pharm. Sci. 54 (1965), No. 8, p. 1156, Table VI.

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