Preparation of aryl-substituted aliphatic carboxylic acid esters

Details Preparation of aryl-substituted aliphatic carboxylic acid esters Preparation of aryl-substituted aliphatic carboxylic acid esters

1993-06-11

1994-01-11

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562406, C07C 6976

Patent

active

052783359

ABSTRACT:
A new process for preparing alkyl esters of ibuprofen is provided. A 1-halo-1-(4-isobutylphenyl)ethane is reacted with carbon monoxide in the presence of an anhydrous alcohol at a temperature between about 10.degree. C. and about 200.degree. C. An excess of several moles of alcohol is preferred. An acid such as trifluoroacetic acid is also added. As catalyst, a mixture of a copper compound and a palladium or a palladium compound and at least one acid-stable ligand are present.

REFERENCES:
patent: 4424394 (1984-01-01), Schneider et al.
patent: 4439618 (1984-03-01), Cometti et al.

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