Preparation of antitumor agent from shellfish

Details Preparation of antitumor agent from shellfish Preparation of antitumor agent from shellfish

1982-08-04

1983-06-28

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 95, 424177, A23J 104, C07G 700

Patent

active

043904688

ABSTRACT:
A new antitumor agent is provided which consists essentially of water-soluble, macromolecular glycoprotein substances having a range of molecular weights within the limits of from 10,000 to 300,000 and which is prepared from shellfish or mollusc by taking up the liquid portion which comes from the cooking of raw shellfish in an aqueous solvent, typically water or a saline solution, or vapor of such solvent and which is to be discarded as waste, concentrating the liquid portion to a smaller volume or to dryness, dissolving the resulting concentrate or dry powder in an aqueous solvent and isolating the desired water-soluble, macromolecular glycoprotein substances therefrom. The isolation of the desired substances is preferably carried out by an ion-exchange chromatography with a basic anion-exchanger followed by a gel-filtration.

REFERENCES:
patent: 3862122 (1975-01-01), Peniston et al.
patent: 4199496 (1980-04-01), Peniston et al.
J. of National Cancer Institute, vol. 60, No. 6, pp. 1499-1500, Jun. 1978, Sasaki et al.

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