Preparation of an antidepressant

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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C07D22328

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active

041720741

ABSTRACT:
The present invention relates to a new and improved method for the preparation of the hydrochloride of 4'-chloro-2-{(3-(10,11-dihydro-5H-dibenz[b,f]azepinyl-(5))-propyl)-methyl- amino}-acetophenone, in the following called lofepramine hydrochloride. In the following, the free base is referred to as lofepramine.

REFERENCES:
Eriksoo et al. (II), Arzheim.-Forsch (Drug Res.), 20, pp. 1561-1569 (1970).

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