Preparation of amorolfine

Details Preparation of amorolfine Preparation of amorolfine

2009-06-22

2011-11-01

Shameem, Golam M (Department: 1622)

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

Reexamination Certificate

active

08049007

ABSTRACT:
Amorolfine base, which is a compound of formula (I):is improvedly prepared by:(i) contacting a compound of formula (II):with a Friedel-Crafts catalyst; and(ii) adding one equivalent of 2-halogeno-2-methylbutane, wherein the reaction mixture obtained in step (i) is cooled to a temperature from −40° to −60° C. prior to step (ii) and the Friedel-Craft catalyst is selected from the group consisting of gallium chloride, antimony pentafluoride, molybdenum pentachloride, indium chloride, antimony pentachloride.

REFERENCES:
patent: 7795425 (2010-09-01), Weber et al.

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