Preparation of aminophosphines

Details Preparation of aminophosphines Preparation of aminophosphines

2005-06-14

2005-06-14

Nazario-Gonzalez, Porfirio (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

C556S144000, C556S148000, C502S162000, C568S846000

Reexamination Certificate

active

06906213

ABSTRACT:
Disclosed is a process for the preparation of phosphine-aminophosphines that are useful in the formation of catalysts useful in carrying out a wide variety of reactions such as asymmetric hydrogenations, asymmetric reductions, asymmetric hydroborations, asymmetric olefin isomerizations, asymmetric hydrosilations, asymmetric allylations, asymmetric conjugate additions, and asymmetric organometallic additions. The process comprises the steps of (1) contacting a compound of formula 2in-line-formulae description="In-line Formulae" end="lead"?R2P—L—NHR3  2in-line-formulae description="In-line Formulae" end="tail"?with phosphorus trihalide PX3in the presence of an inert, organic solvent and an acid acceptor to produce intermediate compound having formula 3(2) contacting intermediate compound 3 with a reactant having the formula R1—M1, R2—M1or a mixture thereof.

REFERENCES:
patent: 6590115 (2003-07-01), Boaz et al.
Schmidt et al, Synthesis, 1984, pp. 53-60.
Schmidt et al, Synthesis, 1992, pp. 487-490.

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