Preparation of aminomethyl-phenylimidazoles

Details Preparation of aminomethyl-phenylimidazoles Preparation of aminomethyl-phenylimidazoles

1997-08-06

1999-05-18

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544333, 544370, 5483355, 5483415, 5483425, C07D403/12;403/14;403/04;403/00

Patent

active

059051523

ABSTRACT:
Aminomethyl-phenylimidazoles are produced by reaction of an ester of a hydroxymethyl-phenylimidazole with an amine. A particularly preferred ester is the acetate ester. The aminomethyl-phenylimidazoles have useful properties as highly selective partial agonists or antagonists at brain dopamine receptor subtypes. A preferred compound prepared is . Esters of the hydroxymethyl-phenylimidazoles are useful intermediates.

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patent: 5633377 (1997-05-01), Thurkauf et al.
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J. March, "Advanced Organic Chemistry," John Wiley & Sons, New York (1985), p. 311, line 26-p. 312, line 8.

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