Preparation of amino acid-substituted benzoylguanidines as diagn

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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514478, 514486, 514634, 514542, 560 27, 562439, 562465, 562469, A61K 31165, A61K 3127, C07C27114, C07C27922

Patent

active

056312938

ABSTRACT:
Amino acid-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent and a medicament containing them
Benzoylguanidines of the formula I ##STR1## in which the radicals R(1) to R(5) have the meanings given in the description, are described. They are prepared by reacting a compound of the formula II ##STR2## in which R(1) to R(5) and L have the meanings given in the description, with guanidine. The compound I is suitable for the preparation of cardiovascular medicaments.

REFERENCES:
patent: 3780027 (1973-12-01), Craqoe et al.
patent: 5091394 (1992-02-01), Englert et al.
patent: 5364868 (1994-11-01), Englert et al.
Derwent Abstract of CA 2,099,445.
Derwent Abstract of DE 3,502,629.
Derwent Abstract of EP 589336.
Derwent Abstract of EP 627413.

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