Preparation of amino acid derivatives

Details Preparation of amino acid derivatives Preparation of amino acid derivatives

1988-01-22

1989-08-08

Brust, Joseph P.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

564136, 564137, 549 9, 549 28, 549 68, 549346, 549424, 549480, 549510, 552 12, C07C10206, C07C11704, C07D30914, C07D33502

Patent

active

048554553

ABSTRACT:
A hydroxy-carboxylate ester is converted to an amino-acid-amide by replacement of the --OH group with --N.sub.3, via, e.g., CH.sub.3 SO.sub.2 Cl and NaN.sub.3 ; reacting with amine to convert the ester to amide; and hydrogenating --N.sub.3 to --NH.sub.2. The present process alleviates the conventional use of blocking-deblocking procedures.

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patent: 4517379 (1985-05-01), Brennan et al.
Streitwieser and Heathcock, Introduction to Organic Chemistry (1985), pp. 767-768.
Tamura et al, Chem. Abstracts 93(5), 1980, Abst. No. 46731n.
Bertho et al, Chem. Abstracts 57(2) 1962, at 2326h.
Scholes et al, Chem. Abstracts 98(25) 1983, Abst. No. 216001 x.
Makino et al, Chem. Abstracts 105 (11), 1986, Abst. No. 97160z.
W. Frederick Huber, JACS 77, pp. 112-116 (1955).

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