Preparation of .alpha..sub.1 -antichymotrypsin

Details Preparation of .alpha..sub.1 -antichymotrypsin Preparation of .alpha..sub.1 -antichymotrypsin

1994-07-29

1996-10-01

Fleisher, Mindy

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530380, 530395, 530415, 530416, 530830, C07K 118, C07K 122, C07K 1447, A61K 3817

Patent

active

055611087

ABSTRACT:
Human .alpha..sub.1 -antichymotrypsin (ACT) can be purified from solutions containing human .alpha..sub.1 -proteinase inhibitor (PI) and antithrombin III (AT-III) using chromatography adsorption steps at carefully controlled pH and conductivity. The separated ACT retains in vitro inhibitory capacity and has potential therapeutic use.

REFERENCES:
patent: 4379087 (1983-04-01), Coan et al.
patent: 5079336 (1992-01-01), Rubin et al.
Travis et al. Biochemistry 17(26) 5647-5651 1978.
Laine et al. Biochim Biophys Acta 668 429-438 1981.
Laine et al. Eur. J. Biochem 197 209-215 1991.
Laine et al Clin Chim Acta 190 163-174 1990.
Abdullah et al. Arch Biochem Biophys. 225(1) 306-312 1983.
Siddiqui et al Biochem Biophys Res. Commun. 95(4) 1737-1742 1980.

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