Preparation of .alpha.,.alpha.-dihaloalkyl boronic esters

Details Preparation of .alpha.,.alpha.-dihaloalkyl boronic esters Preparation of .alpha.,.alpha.-dihaloalkyl boronic esters

1986-02-12

1987-10-20

Sneed, Helen M. S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Borate esters

558288, C07C10702, C07F 504

Patent

active

047015454

ABSTRACT:
Esters of .alpha.,.alpha.-haloalkyl boronic acids are prepared by the addition of an alkali metal dialkylamide, or some other equivalent sterically hindered base to a mixture of a 1,1-dihaloalkane and a trialkyl borate in an organic solvent at a temperature between about -78.degree. C. and +25.degree. C. In one embodiment, diisopropyl (dichloromethyl)borate is formed by the addition of lithium diisopropylamide to a mixture of dichloromethane and triisopropyl borate in the presence of tetrahydrofuran as the solvent medium at a temperature between about -10.degree. C. and +10.degree. C.

REFERENCES:
patent: 4525309 (1985-06-01), Matteson et al.
Rathke et al, J. Orgametal. Chem. 122, pp. 145-149 (1976).

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