Preparation of .alpha.-acylacetamides using tetramethyl guanidin

Details Preparation of .alpha.-acylacetamides using tetramethyl guanidin Preparation of .alpha.-acylacetamides using tetramethyl guanidin

1975-11-25

1978-12-26

Waltz, Thomas

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

544265, 544266, 544287, 560 13, 260302R, 260308R, 260308A, 260559D, 260561K, 260562K, 260558P, 260564A, C07D23500, C07D23972, C07D25306, C07D25304

Patent

active

041317351

ABSTRACT:
A method is described for preparing an .alpha.-substituted-.alpha.-acylacetamide wherein an .alpha.-acyl-.alpha.-halo-acetamide is allowed to react with an organic compound with pKa between 7 and 12 in a medium of an aprotic solvent and in the presence of a tetraalkylguanidine as basic condensing agent.

REFERENCES:
patent: 2009397 (1935-07-01), Goldstein
patent: 2368302 (1945-01-01), Jennings
patent: 2396917 (1946-03-01), Hanford et al.
patent: 2416738 (1947-03-01), Cashion
patent: 2591470 (1952-04-01), Schmid et al.
patent: 3265506 (1966-08-01), Weissberger et al.
patent: 3277155 (1966-10-01), Loria et al.
patent: 3384657 (1968-05-01), Weissberger et al.
Angyal et al., CA 46:11113a, (1952).
Anderson et al., CA 67:68125h, (1967).

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