Preparation of agarose coated, solid agarose-collagen beads cont

Details Preparation of agarose coated, solid agarose-collagen beads cont Preparation of agarose coated, solid agarose-collagen beads cont

1995-06-07

1997-07-01

Naff, David M.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

435177, 435178, 435182, 435382, 435366, A61K 3512, C12N 1102, C12N 1110, C12N 500

Patent

active

056435690

ABSTRACT:
Biological agents such as secretory cells are encapsulated in a hydrophilic gel made of agarose or collagen-agarose and gelatin sponge-agarose combinations. In a preferred embodiment, semi-solid beads are formed from a suspension containing collagen, agarose and secretory cells such as pancreatic islets, the collagen is polymerized to form solid, agarose-collagen beads and the solid beads are coated with agarose. Coating is preferably by rolling the solid beads in about 5-10% agarose, contacting the rolled beads with mineral oil and washing oil from the beads. Beads containing secretory cells can be transplanted into a mammal to treat a condition caused by impaired secretory cell function.

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Brodelius, et al., "Entrapment of Plant Cells In Different Matrices," FEBS Letters: 122(2): 312-316 (1980) was cited by the examiner in the parent application.
Iwata, et al., Journal of Biomedical Materials Research, vol. 26, 1992, pp. 967-977.

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