Preparation of agarose coated, solid agarose-collagen beads...

Details Preparation of agarose coated, solid agarose-collagen beads... Preparation of agarose coated, solid agarose-collagen beads...

2007-04-03

2007-04-03

Naff, David M. (Department: 1651)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

C434S177000, C434S178000, C434S182000, C434S366000, C434S382000, C434S395000, C434S397000

Reissue Patent

active

10336442

ABSTRACT:
Biological agents such as secretory cells are encapsulated in a hydrophilic gel made of agarose or collagen-agarose and gelatin sponge-agarose combinations. In a preferred embodiment, semi-solid beads are formed from a suspension containing collagen, agarose and secretory cells such as pancreatic islets, the collagen is polymerized to form solid, agarose-collagen beads and the solid beads are coated with agarose. Coating is preferably by rolling the solid beads in about 5-10% agarose, contacting the rolled beads with mineral oil and washing oil from the beads. Beads containing secretory cells can be transplanted into a mammal to treat a condition caused by impaired secretory cell function.

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