Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell
Reissue Patent
2004-11-01
2008-10-28
Naff, David M (Department: 1657)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Animal or plant cell
C435S177000, C435S178000, C435S182000, C435S356000, C435S382000, C435S395000, C435S397000
Reissue Patent
active
RE040555
ABSTRACT:
Biological agents such as secretory cells are encapsulated in a hydrophilic gel made of agarose or collagen-agarose and gelatin sponge-agarose combinations. In a preferred embodiment, semi-solid beads are formed from a suspension containing collagen, agarose and secretory cells such as pancreatic islets, the collagen is polymerized to form solid, agarose-collagen beads and the solid beads are coated with agarose. Coating is preferably by rolling the solid beads in about 5-10% agarose, contacting the rolled beads with mineral oil and washing oil from the beads. Beads containing secretory cells can be transplanted into a mammal to treat a condition caused by impaired secretory cell function.
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Jain Kanti
Rubin Albert L.
Smith Barry
Fulbright & Jaworski LLP
Naff David M
The Rogosin Institute
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