Preparation of acyclovir using 1,3 dioxolane

Details Preparation of acyclovir using 1,3 dioxolane Preparation of acyclovir using 1,3 dioxolane

1995-04-27

1996-10-22

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

C07D47318

Patent

active

055678165

ABSTRACT:
A process for the preparation of acyclovir includes contacting an at least partially silylated guanine or mixture of at least partially silylated guanines with 1,3-dioxolane in the presence of a selective alkylation catalyst selected from the group consisting of trifluoromethanesulfonic acid, trimethylsilyl trifluoromethanesulfonate, and bistrimethylsilyl sulfonate, and hydrolyzing the product thus formed.

REFERENCES:
patent: 4360522 (1982-11-01), Schaeffer et al.
patent: 4803272 (1989-02-01), Anton et al.
Partial Abstract for JP 62-151189 (1986).
M. M. Mansuri et al., "1-(2-Deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-ethyluracil. A Highly Selective Antiherpes Agent", J. Med. Chem., 30(5), pp. 867-871 (1987).
W. T. Ashton et al., "Synthesis and Antiherpetic Activity of (S)-, (R)-, and (.+-.)-9-[2,3-Dihydroxy-1-propoxy)methyl]guanine, Linear Isomers of 2'-Nor-2'-deoxyguanosine", J. Med. Chem., 28(7), pp. 926-933 (1985).
M. Madre et al., "Analogs of Purine Nucleosides. I. Methods for Synthesis of 9-(2-hydroxyethoxymethyl)guanine-Acycloguanosine", Khim.-Farm. Zh., 19(11), pp. 1371-1375 (1985).
S. V. Kochetkova et al., "Simple and Convenient Method for the Synthesis of Guanosine Acyclic Analogs", Bioorg. Khim., 15(1), pp. 133-135 (1989).
I. P. Smirnov et al., "Compounds Related to Acyclovir. III. Synthesis of Analogs of 5'-Deoxynucleosides", Bioorg. Khim., 14(7), pp. 921-925 (1988).
I. P. Smirnov et al., "Compounds Related to Acyclovir. VI. Synthesis of OPtically Active 1',2'-Seconucleosides", Bioorg. Khim., 16(10), pp. 1355-1361 (1988).
J. Kjellberg et al., Nucleosides & Nucleotides, 8(2), pp. 225-256 (1989).
Zhongguo Yaoke Daxue Zuebao, 23(1), pp. 43-44 (1992).
F. P. Clausen et al., Org. Prep. Proced. Int., 25(4), pp. 375-401 (1993).
H. Matsumoto et al., Chem. Pharm. Bull., 36(3), pp. 1153-1157 (1988).

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