Preparation of active proteins cross-linked to inactive proteins

Details Preparation of active proteins cross-linked to inactive proteins Preparation of active proteins cross-linked to inactive proteins

1975-01-15

1977-01-25

Naff, David M.

Textiles: fiber preparation

195 59, 195 63, 195DIG11, 260112R, 424 94, C07G 702, C07G 700

Patent

active

040049795

ABSTRACT:
Articles containing active proteins, such as enzymes, crosslinked to an inactive protein are prepared by dispersing and reacting in a solvent an active protein and an inactive protein simultaneously with a crosslinking agent to crosslink the active and inactive proteins together. The degree of crosslinking can be controlled by introducing tris (hydroxymethyl) aminomethane in an amount sufficient to stop chain growth. Optionally, an inert carrier may be present during crosslinking. The resultant crosslinked active and inactive proteins can be in various forms such as solutions, suspensions, gels, films, membranes, granules, pills or tablets.

REFERENCES:
patent: 3639558 (1972-02-01), Csizmas et al.
Avrameas et al., Biologically Active Water-Insoluble Protein Polymers, Journal of Biological Chemistry, vol. 242, No. 7, 1967 (pp. 1651-1659).
Silman et al., Some Water-Insoluble Papain Derivatives, Biopolymers, vol. 4, 1966 (pp. 441-448).
Habeeb, A.F.S.A., Preparation of Enzymically Active Water-Insoluble Derivatives of Trypsin, Archives of Biochemistry and Biophysics, vol. 119, 1967 (pp. 264-268).
Goldman et al., Papain Membrane on a Collodion Matrix Science, vol. 150, 1965 (pp. 758-760).

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