Preparation of acid chlorides

Details Preparation of acid chlorides Preparation of acid chlorides

1997-11-07

1999-02-16

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic halides

C07C 5158

Patent

active

058722904

ABSTRACT:
Disclosed is a method of making an acid chloride having the general formula ##STR1## where each R contains no unsaturated groups and is preferably independently selected from aliphatic from C.sub.1 to C.sub.7 and aryl from C.sub.6 to C.sub.15. A solution is formed in an inert solvent of an aldehyde having the general formula ##STR2## and chlorine gas is sparged into said solution. The reaction between the aldehyde and the chlorine gas to produce the acid chloride is performed in the absence of a catalyst, an initiator, and ultraviolet light. A chlorinated acid chloride can be prepared from the acid chloride by reacting it with additional chlorine in the presence of a chlorine free radical generator.

REFERENCES:
patent: 4388251 (1983-06-01), Clifford
Advanced Organic Chemistry by Jerry March, Fourth Edition p. 697 (1992).
An Article by Franz Effenberger et al., Titled Enzyme Catalyzed Addition of Hydrocyanic Acid to Substituted Pivaldehydes--A Novel Synthesis of (R)-"Pantolactone" in Tetrahedron: Asymmetry, vol. 6, No. 1--pp. 271 to 282 (1995).
Organic Synthesis, Collective vol. I 2nd Edition (1958), pp. 155 to 156 by H. T. Clarke et al.

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