Preparation of a recombinant subunit vaccine against pseudorabie

Details Preparation of a recombinant subunit vaccine against pseudorabie Preparation of a recombinant subunit vaccine against pseudorabie

1988-02-03

1991-12-03

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Lymphokine

435 5, 4351723, 4352351, 4353201, 530826, 935 59, 935 63, A61K 3912, C12N 1500

Patent

active

050699016

ABSTRACT:
A method of preparation of a vaccine for use in immunizing animals against pseudorabies virus (PRV) infection which comprises inactivated recombinant PRV subunit antigens. Also described is a diagnostic kit for detection of PRV infection which distinguishes vaccinated animals from naturally exposed animals.

REFERENCES:
patent: 4603112 (1986-07-01), Paoletti et al.
patent: 4711850 (1987-12-01), Kit et al.
patent: 4810634 (1989-03-01), Post et al.
Wiktor et al., "Protection from Rabies by a Vaccinia Virus Recombinant Containing the Rabies Glycoprotein Gene", Proc. Natl. Acad. Sci. USA, vol. 81, pp. 7194-7198, 1984.
Marchioli et al., "Evaluation of Pseudorabies Virus Glycoprotein gp 50 as a Vaccine for Aujeszky's Disease in Mice and Swine: Expression by Vaccinia Virus and Chinese Hamster Ovary Cells", J. Virol., vol. 12, pp. 3977-3982, 1987.
Petrovskis et al., "Use of .lambda.gt11 to Isolate Genes for Two Pseudorabies Virus Glycoproteins with Homology to Herpes Simplex Virus and Varicella-Zoster Virus Glycoproteins", J. Virol., vol. 60, No. 1, pp. 185-193, 1986.
Cremer et al., "Vaccinia Virus Recombinant Expressing Herpes Simplex Virus Type 1 Glycoprotein D Prevents Latent Herpes in Mice", Science, vol. 228, pp. 737-740, 1985.
Petrovskis et al., Pseudorabies Virus Protein, 9 Apr. 1987, PCT WO87-02058.
Post et al., Virus Vaccine, 12 Feb. 1987, PCT WO87-00862.

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