Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Patent
1989-09-29
1992-02-18
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
424 851, 530402, 530409, 530351, 514 2, A61K 31745, A61K 4505, C07K 1700
Patent
active
050892614
ABSTRACT:
The present invention is a process for preparing a pharmaceutical composition comprising a biologically active conjugated protein. It comprises a polyethylene glycol or a polyoxyethylated polyol conjugated to IL-2. This protein is conjugated to reduce its immunogenicity, and increase its solubility, and increase its circulating in vivo half-life.
REFERENCES:
patent: 4604377 (1986-08-01), Fernandez et al.
patent: 4766106 (1988-08-01), Katre et al.
patent: 4818769 (1989-04-01), Nunberg et al.
Veronese, "Surface modification of proteins," Applied Biochem and Biotechnology, vol. 11, 1985, p. 141.
Dayhoff, M., Atlas of Protein Sequence & Structure, vol. 5:89-99, 1972.
Aldwin Lois
Goodson Robert J.
Katre Nandini
Nitecki Danute E.
Cetus Corporation
McGarrigle Philip L.
Perkins Susan M.
Schain Howard E.
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