Preparation of a polymer/interleukin-2 conjugate

Details Preparation of a polymer/interleukin-2 conjugate Preparation of a polymer/interleukin-2 conjugate

1989-01-23

1990-02-20

Schofer, Joseph L.

Drug, bio-affecting and body treating compositions

Lymphokine

424 78, 424 851, 514 2, 530351, A61K 31745, A61K 3174, A61K 3900, A61K 3700

Patent

active

049025023

ABSTRACT:
The present invention is a process for preparing a pharmaceutical composition comprising a biologically active conjugated protein. It comprises a polyethylene glycol or a polyoxyethylated polyol conjugated to IL-2. This protein is conjugated to reduce its immunogenicity, and increase it solubility, and increase its circulating in vivo half-life.

REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 4412989 (1983-11-01), Iwashita et al.
patent: 4732863 (1988-03-01), Tomasi et al.
patent: 4766106 (1988-08-01), Katre et al.
patent: 4794002 (1988-12-01), Hems et al.
Beauchamp et al., 1983, Anal. Biochem. 131:25-33.
Veronese et al., 1985, Applied Biochemistry and Biotechnology 11:141-152.

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