Preparation of a monoclonal antibody specific to human myelomono

Details Preparation of a monoclonal antibody specific to human myelomono Preparation of a monoclonal antibody specific to human myelomono

1995-06-07

1996-09-10

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

424 855, 435 705, 4352402, 43524026, 436548, 530351, C12P 2104, A61K 3766, G01N 3353, C07K 700

Patent

active

055545157

ABSTRACT:
A human myelomonocyte interferon-gamma having a novel polypeptide and carbohydrate chain structure is produced by propagation of an established human myelomonocyte in vitro or after being implanted in a non-human warm-blooded animal or in a diffusion chamber placed inside or outside the body of the animal. The human myelomonocyte may be contacted with an inducer during propagation. A monoclonal antibody specific to the human myelomonocyte interferon-gamma is produced by immunizing a non-human warm-blooded animal with purified human myelomonocyte interferon-gamma as an antigen, recovering an antibody producing cell from the animal and fusing the cell with a myeloma cell to produce a hybrid capable of producing the monoclonal antibody. The human myelomonocyte interferon-gamma can be purified by chromatography with an anti-human myelomonocyte interferon-gamma antibody such as the monoclonal antibody. The human myelomonocyte interferon-gamma can be used as a prophylactic and therapeutic agent for human interferon-gamma susceptive diseases.

REFERENCES:
patent: 4791101 (1988-12-01), Adolf
patent: 4939178 (1990-07-01), Muller
patent: 4946674 (1990-08-01), von Eichborn et al.
patent: 5407811 (1995-04-01), Montagnier et al.
patent: 5422239 (1995-06-01), Wands et al.
Miyata et al. (1987) J. Biochem. 99 1681-1688.
Braude (1984) Biochemistry 23 5603-5609.
Gray et al (1982) Nature 295: 503-508.
Devos et al (1984) J. Interferon Res. 4 461-468.
Yamamoto et al., Studies on the Sugar Chains of Interferon from Human Peripheral-Blood Lymphocytes, J. Biochem. 105:1034-1039 (1989).

Affiliated with

Also associated with

Rating

Preparation of a monoclonal antibody specific to human myelomono does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of a monoclonal antibody specific to human myelomono, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of a monoclonal antibody specific to human myelomono will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1319858