Preparation of a cephalosporin antibiotic using the syn-isomer o

Details Preparation of a cephalosporin antibiotic using the syn-isomer o Preparation of a cephalosporin antibiotic using the syn-isomer o

1995-02-02

1997-01-14

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D50156

Patent

active

055941303

ABSTRACT:
The present invention provides an aqueous acylation process for the preparation of antibiotic, cefepime dihydrochloride hydrate which is substantially free of the anti-isomer and the .DELTA..sup.2 isomer comprising the N-acylation of 7-amino-3-[(1-methyl-1-pyrrolidinio)-methyl]ceph-3-em-4-carboxylate with the syn-isomer of 2-(2-aminothiazol-4-yl)-2-methoxyimino acetyl chloride hydrochloride.

REFERENCES:
Mandel, et al., Collect Czech. Chem. Commun., 54: 1734-1745 (1989).

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