Preparation of 9-.alpha.-hydroxy-17-keto steroids using Mycobact

Details Preparation of 9-.alpha.-hydroxy-17-keto steroids using Mycobact Preparation of 9-.alpha.-hydroxy-17-keto steroids using Mycobact

1992-08-06

1994-03-29

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing a...

435 55, 435 56, 435 58, 435 61, 4352531, C12N 120, C12P 3300, C12P 3306, C12P 3302

Patent

active

052983986

ABSTRACT:
9.alpha.-hydroxy-17-keto steroids are prepared by fermenting steroids having a C-17-side chain of 5-10 carbon atoms inclusive, with the novel Mycobacterium species CBS 482.86. Starting from various substrates containing a 5-10 C carbon chain on C-17, 9.alpha.-hydroxyandrost-4-ene-3,17-dione, 7.alpha.,9.alpha.,12.alpha.-trihydroxyandrost-4-ene-3,17-dione or 9.alpha.-hydroxyandrost-4,11-diene-3,17-dione is obtained in high yield. The resulting compounds are useful intermediates in the synthesis of therapeutically important steroids, particularly corticosteroids.

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