Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-07-12
2009-10-27
Saeed, Kamal A (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
07608722
ABSTRACT:
A process for preparing 1,7′-dimethyl-2′-propyl-2,5′-bi-1H-benzimidazole of formula (I)reacting N-methyl-o-phenylenediamine of formula (II) or the salts thereofwith 2-propyl-4-methyl-1H-benzimidazole-6-carboxylic acid of formula (III) or the salts thereofwherein the coupling and cyclization is achieved using 1,3,5-triazine and tertiary amine.
REFERENCES:
Ries, Uwe, et al; 6-Substituted Benzimidazoles as New Nonpeptide Angiotensin II Receptor Antagonists: Synthesis, Biological Activity, and Structur-Activity Relationships; J. Med. Chem, 1993, 36, 4040-4051; XP-002135628.
Kaminski, Zbigniew; 2-Chloro-4,6-Disubstituted-1,3,5-Triazines, A Novel Group of Condensing Reagents, Tetrahedron Letters, vol. 26, No. 24, pp. 2901-2904, 1985, XP 001018670.
Venkataraman, K, and Wagle, D.R.; Cyanuric Chloride: A Useful Reagent for Converting Carboxylic Acids into Chlorides, Esters, Amides and Peptides; Tetrahedron Letters, vol. 32, pp. 3037-3040- XP 002403117.
Hipskind, Philip A., et al; Practical and Enantiospecific Synthesis of LY303870, a novel NK-1 Antagonist, J. Org. Chem. 1995, 60, 7033-7036; XP2403118A.
Dach Rolf
Heitger Helmut
Rodriguez-Dehli Juan M.
Boehringer Ingelheim International GmbH
Devlin Mary Ellen M.
Morris Michael P.
Saeed Kamal A
Witkowski Timothy X.
LandOfFree
Preparation of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Preparation of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4125946