Preparation of...

Details Preparation of... Preparation of...

2006-07-12

2009-10-27

Saeed, Kamal A (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07608722

ABSTRACT:
A process for preparing 1,7′-dimethyl-2′-propyl-2,5′-bi-1H-benzimidazole of formula (I)reacting N-methyl-o-phenylenediamine of formula (II) or the salts thereofwith 2-propyl-4-methyl-1H-benzimidazole-6-carboxylic acid of formula (III) or the salts thereofwherein the coupling and cyclization is achieved using 1,3,5-triazine and tertiary amine.

REFERENCES:
Ries, Uwe, et al; 6-Substituted Benzimidazoles as New Nonpeptide Angiotensin II Receptor Antagonists: Synthesis, Biological Activity, and Structur-Activity Relationships; J. Med. Chem, 1993, 36, 4040-4051; XP-002135628.
Kaminski, Zbigniew; 2-Chloro-4,6-Disubstituted-1,3,5-Triazines, A Novel Group of Condensing Reagents, Tetrahedron Letters, vol. 26, No. 24, pp. 2901-2904, 1985, XP 001018670.
Venkataraman, K, and Wagle, D.R.; Cyanuric Chloride: A Useful Reagent for Converting Carboxylic Acids into Chlorides, Esters, Amides and Peptides; Tetrahedron Letters, vol. 32, pp. 3037-3040- XP 002403117.
Hipskind, Philip A., et al; Practical and Enantiospecific Synthesis of LY303870, a novel NK-1 Antagonist, J. Org. Chem. 1995, 60, 7033-7036; XP2403118A.

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