Preparation of 7-acylamino-3-(thio-substituted)-methyl 3-cephem-

Details Preparation of 7-acylamino-3-(thio-substituted)-methyl 3-cephem- Preparation of 7-acylamino-3-(thio-substituted)-methyl 3-cephem-

1981-08-28

1983-04-12

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 21, 544 27, C07D50104

Patent

active

043799230

ABSTRACT:
A novel process for the preparation of 7-acylamino-3-(thio-substituted)-methyl-3-cephem-4-carboxylic acid 1-oxide derivatives comprising reacting a 7-acylamino-3-bromomethyl-3-cephem-4-carboxylic acid-1-oxide derivative with a silylated thiol of the formula

REFERENCES:
patent: 3658799 (1972-04-01), Eardley et al.
patent: 4148817 (1979-04-01), Wright
patent: 4266049 (1981-09-01), Bonjooklian
patent: 4284766 (1981-08-01), Laing et al.

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