Preparation of (6s)-6,8-dihydroxyoctanoic esters

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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560145, 560180, C07D33904, C07C 6966

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055301436

ABSTRACT:
(6S)-6,8-Dihydroxyoctanoic esters I ##STR1## (R.sup.1 =alkyl, cycloalkyl, aralkyl or aryl), are prepared by reducing a (3S)-3-hydroxyoctanedioic diester II ##STR2## (R.sup.2 =an R.sup.1 radical group) with a complex hydride and are mainly used as intermediates for synthesizing compounds of the type of liponic acid.

REFERENCES:
patent: 2875227 (1959-02-01), Walton et al.
patent: 2875238 (1959-02-01), Holly et al.
patent: 4772727 (1988-09-01), Sutherland et al.
patent: 4966732 (1990-10-01), Giray et al.
Brookes et al. J. Chem. Soc. Perkin Trans. I (1988), pp. 9-12.
Gopalan et al, "Stereochemical Control of Yeast Reductions: Synthesis of R-(+)-.alpha.-Lipoic Acid," Tet. Lett., vol. 30, No. 42, pp. 5705-5708, (1989).
E Jellum et al., Biomedical and Environmental Mass Spectrometry, vol. 16, pp. 57-62 (1988).
J. Svendsen et al., (I), Organic Mass Spectrum, vol. 22, No. 7, pp. 421-429 (1988).
J. Svendsen et al., (II), Chromatography and Mass Spectrometry in Nutrition Science and Food Safety, pp. 223-234, Elsevier Science (1984).
F. Carey et al., "Advanced Organic Chemistry" 2nd ed., pp. 199-203, Plenum Press, New York (1983).
J. March, "Advaned Organic Chemistry" 2nd ed. pp. 829-831 McGraw-Hill Book Co., New York (1977).
Jellum et al, Chemical Abstracts 110:150863n, p. 384, abstract of Biomed Environ. Mass Spectrom. 1987 (pub 1988), 16(1-n), 57-62 (1989).
Svendsen et al. (I) Chemical Abstracts 109:231121a, p. 875, abstract of Org. Mass Spectrum 1987, 22(7), 421-9 (1988).
Svendsen et al. (II) Chemical Abstracts 101:208080n, p. 396, abstract of Anal. Chem. Symp. Ser. 1984, 223-34 (1984).
J March, "Advanced Organic Chemistry" 3rd ed. pp. 104-107, John Wiley & Sons, N.Y. (1985).

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